Annexin A2 versus Alpha-Fetoprotein in Diagnosing Hepatocellular Carcinoma: A Diagnostic Meta-Analysis

Erick Thokerunga *

Department of Clinical Laboratory Medicine, Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.

Abdullahi Omar Ahmed

Department of Oncology, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China.

Mbasani Rogious

Department of Clinical Laboratory Diagnosis, Jinzhou Medical University, Jinzhou, 40, China.

*Author to whom correspondence should be addressed.


Abstract

Background: Alpha-fetoprotein (AFP) remains widely used for diagnosing hepatocellular carcinoma (HCC) despite its low sensitivity and specificity. Recently, Annexin A2, a highly expressed protein in HCC and almost undetectable in normal liver cells has been studied as a potential alternative.

Objective: To synthesize evidence for the diagnostic accuracy of annexin A2 as an alternative to AFP in the diagnosis of hepatocellular carcinoma.

Methods: PubMed, Embase, PsycINFO, and the China National Knowledge Infrastructure (chkd-cnki) databases were searched without time constraints up to 2022. Meta-analysis was conducted using Meta-Disc software. 

Results: 6 studies were meta-analyzed. The pooled sensitivity and specificity for Annexin A2 were 84% [95% CI :( 80 – 87)], and 78% [95% CI :( 71 – 84)] respectively, while AFP was 70% [95% CI :( 66 – 74)] and 79% [95% CI :( 72 – 85)] respectively. The pooled diagnostic odds ratio was 20.35 [95% CI :( 9.76 – 42.42)] for Annexin A2, and 9.71 [95% CI :( 5.27 – 17.88)] for AFP. The area under the curve (AUC) was 0.88 for Annexin A2 and 0.82 for AFP.

Conclusions: Annexin A2 is significantly more sensitive than AFP for HCC diagnosis but less specific. A combination of Annexin A2 and AFP could improve accuracy.

 

Keywords: Annexin A2, alphafeto protein, meta-analysis, hepatocellular carcinoma


How to Cite

Thokerunga, E., Ahmed, A. O., & Rogious, M. (2022). Annexin A2 versus Alpha-Fetoprotein in Diagnosing Hepatocellular Carcinoma: A Diagnostic Meta-Analysis. Advances in Research, 23(3), 1–12. https://doi.org/10.9734/air/2022/v23i330331