Assessing Respiratory Inflammation among Children Living Near to Non-sanitary Landfill Using Interleukin-6 (IL-6)

Sharifah Norkhadijah S. Ismail *

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

Muhammad S. Othman

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

Dora E. Jamaluddin

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

Sarva M. Praveena

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

Ho Y. Bin

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

Emilia Z. Abidin

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

Aini Syuhaida A. Wahab

Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Malaysia

A. Haryati

Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University, 56000 Kuala Lumpur, Malaysia

*Author to whom correspondence should be addressed.


Abstract

Aims: To determine the respiratory inflammation among children living near to non-sanitary municipal solid waste landfill area and the concentration of Interleukin-6 cytokine.

Study Design: A cross-sectional comparative study design.

Place and Duration of Study: Sample: Pajam, Negeri Sembilan, Malaysia, between September 2013 and April 2014.

Methodology: A total of 72 children were randomly selected based on the inclusive and exclusive criteria. A set of pre-tested questionnaires were utilized to obtain socio-demographic information and to predict health risk faced by the respondents. Saliva samples of the respondents were collected and analyzed using Human Interleukin-6 (IL-6) Platinum ELISA (Enzyme-Linked Immunosorbent Assay) kit.

Results: The PM10 concentration for the exposed group was higher than the unexposed group with the mean ± standard deviation (SD) of 152.31±31.07 μg/m3 and 87.77±30.77 μg/m3 respectively. The mean ± SD of the Interleukin-6 for the exposed group was slightly higher than the unexposed group with the mean ± SD of 6.34±1.95 pg/ml and 5.77±1.08 pg/ml respectively. The most common symptoms reported was sneezing and sore throat. There was no significant correlation between PM10 concentration and IL-6 in this study.

Conclusion: The findings exhibit that there was no association between Interleukin-6 and PM10 concentration of the respondent. However, there are likely potential adverse health impacts arising from particulates exposure among exposed children in this study. Respondents are advised to have a medical check-up in order to determine respiratory health status thus elimination the risks of acquiring respiratory inflammation.

 

Keywords: Respiratory inflammation, children, landfill, saliva, Interleukin-6


How to Cite

Norkhadijah S. Ismail, Sharifah, Muhammad S. Othman, Dora E. Jamaluddin, Sarva M. Praveena, Ho Y. Bin, Emilia Z. Abidin, Aini Syuhaida A. Wahab, and A. Haryati. 2014. “Assessing Respiratory Inflammation Among Children Living Near to Non-Sanitary Landfill Using Interleukin-6 (IL-6)”. Advances in Research 3 (4):404-16. https://doi.org/10.9734/AIR/2015/14478.

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