Preparation and Biomineralization of Injectable Hydrogel Composite Based Chitosan-tetronic and BCP Nanoparticles

Thi Phuong Nguyen

Institute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City 700000, Vietnam

Ngoc Quyen Tran *

Institute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City 700000, Vietnam

*Author to whom correspondence should be addressed.


Abstract

In this study, a hydrogel composite was enzymatically prepared with rapid gelation time from tyramine-tetronic-conjugated chitosan and biphasic calcium phosphate (BCP) nanoparticles. Compressive stress of the hydrogel composite was reached at 591±20 KPa with 10 wt% of loaded BCP. Degradation study of the material showed 20% of weight loss after 4 weeks. In vitro study with MG 63 osteoblast cell evidenced that the cells were well-attached on hydrogel composite surfaces. Biomineralization on the hydrogel composites surfaces was well-observed after soaking for 14 days in simulated body fluid (SBF) solution. The obtained results indicated that the hydrogel composite could be an injectable potential material for bone regeneration.

Keywords: Biomineralization, injectable, hydrogel composite, BCP nanoparticles, bone regeneration


How to Cite

Nguyen, Thi Phuong, and Ngoc Quyen Tran. 2016. “Preparation and Biomineralization of Injectable Hydrogel Composite Based Chitosan-Tetronic and BCP Nanoparticles”. Advances in Research 7 (2):1-8. https://doi.org/10.9734/AIR/2016/25891.

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